WordPress 3.0 offers with the Mu system inbuilt and there is no need to download and install the WordPress mu script because you just need to set some settings and the blog is ready. Just upgrade your current WordPress blog to the latest version and then make sure you are logged into the Dashboard & Ftp to get started.
First access the wp-config.php file and then add the following line of code in the file. You can place it just before this line which can be found almost at the end of the wp-config file. ‘/* That’s all, stop editing! Happy blogging. */’. Once this is done you will find a new option under the Tools panel under the Wp-Admin section.
define (‘WP_ALLOW_MULTISITE’, true ) ;
Click on your Blog > Wp-Admin > Tools >